Use of Collagenase Clostridium histolyticum to Decrease Muscle Fiber Bundle Stiffness in Cerebral Palsy (2019)

Muscle stiffness in cerebral palsy has been associated with an increase in collagen in the space between muscle cells.

If collagenase injections reduce stiffness, the need for surgical intervention to achieve the same outcome may be reduced.

Research Questions

  • Can injections of collagenase reduce the amount of muscle stiffness?

Dr. Jason J Howard MD, Dr. Walter L Herzong PhD, Dr. Timothy Leonard PhD, Dr. James S. Huntley MD, Prof. H. Kerr Grahm MD, Dr. M. Wade Schrader MD