Hypoxemia and White Matter Development in the Motor Outcomes of Extremely Preterm Infants (2017)

Researchers are non-invasively studying the brains of premature infants using advanced MRI techniques to determine the relationship between oxygen levels provided in the hospital and the impact on outcome with respect to cerebral palsy. Although low levels of oxygen related to prematurity are known to cause damage to the brain, further damage could also be caused by giving too much supplemental oxygen. This research can thus lead us on the path to prevention of some causes of cerebral palsy.

Initial Observations

  • Infants who are born early are at higher risk for CP.
  • Preterm infants often have low oxygen levels, which is correlated with brain injuries and potentially disorders like CP.
  • The biological connection between oxygen levels and potential diseases is not understood.

Core Questions

  • What is the relationship between low oxygen levels and conditions that lead to brain injuries?
  • What is the relationship between low oxygen levels and brain injuries?
  • What is the relationship between low oxygen levels and disorders like CP?

Dr. Soo Hyun Kwon MD MHS, Dr. Gordon Sze MD FACR, Dr. Wade Schulz MD PhD